Our investigational therapeutic treatment is based on epicutaneous immunotherapy, or EPIT™. This potential new class of immunotherapy is designed to deliver microgram amounts of allergens to the immune system through intact skin using our proprietary Viaskin™ technology.
In addition to food allergies, Viaskin technology is also being investigated as a treatment option for other immunological disorders. Additional applications for Viaskin, such as use as a diagnostic tool for non-IgE-mediated milk allergy or as a non-invasive method for delivering vaccines against certain diseases, are also being investigated.
The information contained in this video is under clinical investigation. Products utilizing Viaskin patch technology are for investigational use only and have not been approved by the FDA, or by any other regulatory authority, for any use.
The skin’s ability to promote a tolerogenic immune profile in response to allergen exposure makes it a promising route for allergen immunotherapy. Our investigational approach to EPIT aims to target specific cells in the epidermis, such as Langerhans cells, in order to activate the immune system. Pre-clinical research has shown that these cells capture allergens and migrate to the lymph node where they activate specific regulatory T cells (Tregs). The specific Tregs activated by EPIT with Viaskin can down-regulate the Th2-oriented reaction to the allergen, which leads to suppression of an allergic response.
The Viaskin patch contains a deposit of dry allergen at its center, that sits above the skin on a backing film. When the patch is applied to intact skin, a condensation chamber is formed between the allergen and the top layer of skin, the epidermis.
Natural water loss from the skin accumulates within the condensation chamber, solubilizing the allergen (in green). Once solubilized, the allergen is available for absorption into the epidermis.
Within the epidermis, the allergen is captured by antigen-presenting cells, such as Langerhans cells (LC). Based on animal studies of EPIT with Viaskin, there is no penetration of the allergen beyond the epidermis, limiting its access to the bloodstream.
Langerhans cells carrying the allergen migrate to the lymph nodes, where they induce specific T regulatory cells capable of suppressing the allergic response.